#Rutin
#Flavonoids
DEFINITION
Rutin is a flavonoid, and a complex sugar called a glycoside. Flavonoids are plant melanin, the pigments we find in plants, as well as the 'collagen' we find in fruits like an orange. I’m defining the white parts of a citrus fruit, the webbing that keeps it all together, and the white part of the rind, as plant collagen.
https://en.wikipedia.org/wiki/Flavonoid
Its easy to imagine the protective and strengthening effect a plant gets from its pigment and collagen, in the same way that we need collagen to keep our body tightly bound, and melanin/pigment in our skin to protect us from the sun, and to detox.
There are three kinds of flavonoids:
Bioflavonoids, including rutin
Isoflavonoids
Neoflavonoids
In this article, I concentrate mostly on rutin, which I find to be the most readily available in foods and supplements, and the most researched flavonoid.
I have found no research that shows we could be chronically or acutely poisoned from ingesting too much rutin. They're have been studies where rats were given the human equivalent of about 20 grams a day, and there were no toxic effects.
http://journals.sagepub.com/doi/abs/10.3181/00379727-64-15781
The one caveat is that rutin may thin the blood so much that it can cause a pregnant woman to have a miscarriage. If you are pregnant, talk to your doctor before supplementing with rutin.
HISTORY
Rutin is named after the herb rue, ruta graveolens, which has a long history of use in human culture and medicine.
https://en.wikipedia.org/wiki/Ruta_graveolens
Our ancestors new the importance of rutin, just like the ancient Romans and the Indians of the Northwest knew of the importance of fish oil to land-locked humans more than 6000 years ago.
The Power Of iodine
http://www.mercuryfreekids.org/mercury101/2016/11/22/iodine-our-most-important-element
At one time flavonoids were collectively called Vitamin P. There appears to have been found 4000-8000 different types of flavonoids. It is claimed that flavonoids are no longer called Vitamin P because there is no definitive Flavonoid. It appears that they, whoever is pulling the strings behind the scenes, just decide to leave flavonoids on the shelf, and not name it anything. Maybe it will just ‘go away?’
If Flavonoids are so great, why haven't we heard more about them? My take is that it is not profitable for the drug industry because it is actually a cure for so many of our problems. Flavonoids may literally work too well, and they have no cases where it is hurting people, so they just don't talk about it.
In this Wikipedia article, rutin is dismissed as a kind of 'thing' that somebody will study at some point in the future, when we they have the time to do it.
“Rutin (rutoside or rutinoside) and other dietary flavonols are under preliminary clinical research for their potential biological effects, such as in reducing post-thrombotic syndrome, venous insufficiency, or endothelial dysfunction, but there was no high-quality evidence for their safe and effective uses as of 2016.”
https://en.wikipedia.org/wiki/Rutin
Compare that to the little bit of history I could find about Vitamin P, and the only way I found this was to look up the history of the 1936 Noble Prize winner for discovering vitamin C, Albert Szent-Gyorgi, who also discovered Flavonoids, and then spent the next 40 years studying them.
http://historyofsciences.blogspot.com/2012/06/discovery-of-flavonoid.html
Flavonoids help the body utilize Vitamin C more efficiently, as well as help produce collagen (the skin’s main building blocks). There are more than 130 registered therapeutic medicinal preparations containing rutin.
Clearly, Wikipedia is not giving us the full story.
SOURCES
The best sources of rutin would be eating fruits, vegetables, and herbs in their natural states. However, many of us are dealing with large-scale poisonings, and we may need concentrated forms of rutin, to return more quickly to our homeostasis, our natural, un-poisoned state.
Rutin and other bioflavonoids are found in:
asparagus
buckwheat
broccoli
brussel sprouts
fruit
fruit rinds, especially citrus fruits
berries
apple peels
black tea
rooibos tea
Here is a list of some additional sources of rutin.
https://en.wikipedia.org/wiki/Rutin#In_food
This article lists three different forms of flavonoids, Quercetin, Rutin, and Curcurmin. Curcurmin is Turmeric. Keep taking turmeric if you are already using it.
There is a little bit of misinformation here, although I like that they say it can prevent cancer. It is not exactly clear how a flavonoid like rutin works, and it is not a nutrient. It is more involved in cell signaling, and structure, and it may be our basic substrate.
What Is Vitamin P, and How Can It Help Prevent Cancer?
https://thetruthaboutcancer.com/vitamin-p-cancer/
The best sources of flavonoids from our fruits and veggies, and/or from supplements that have multiple flavonoids in them, similar to what we find in nature.
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Hesperidin is a natural bioflavonoid, and its name means ‘citrus.
What Is Hesperidin (Vitamin P)?
https://www.livestrong.com/article/342775-what-is-hesperidin-vitamin-p/
Allergies… Nothing to Sneeze at!
“Quercetin is especially effective for allergy symptom overload because it stabilizes mast cell membranes and prevents the release of histamine and other inflammatory agents. “
https://www.needs.com/product/NDNL-0705-01/a_Quercitin
Sources of Quercetin
https://en.wikipedia.org/wiki/Quercetin#Occurrence
BENEFITS OF RUTIN
The following article has a large list of supplemental benefits of rutin. Look for the prefix ‘ANTI’, as the authors add it to just about everything. Anti-cancer, anti-diabetes, anti-inflammatory, etc.
The Pharmacological Potential of Rutin
https://www.sciencedirect.com/science/article/pii/S1319016416300263#b0070
Phytochemicals – 12 Health Benefits of Rutin
http://kylenorton.healthblogs.org/2011/12/01/phytochemicals-12-health-benefits-of-rutin/
If rutin makes every drug that much more effective, and there are no negative reports for rutin, then we don’t need more drugs, do we? Maybe we just need more rutin.
Here is a breakdown, in alphabetical order, of the research I have discovered in regards to the benefits of rutin on disease.
AMMONIA
Rutin is clearing out the ammonia, and for many people, left over ammonia metabolites are a big problem.
Influence of rutin on biochemical alterations in hyperammonemia in rats.
https://www.ncbi.nlm.nih.gov/pubmed/21382703
ANTI-INFLAMMATORY ACTIVITY
I’m giving some lengthy quotes here because they are so good. These articles also list other benefits of rutin.
Rutin Supplement Health Benefit by Ray Shahelian
“Rutin inhibits platelet aggregation, making the blood thinner and improves circulation… Rutin inhibits metabolic aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose (sugar - glucose) into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy and neuropathy. Substances that prevent or slow the action of aldose reductase are being studied as a way to prevent or delay these complications of diabetes. Aldose reductase is the first enzyme in the sorbitol pathway. This pathway is responsible for the conversion of glucose to sorbitol, and of galactose to galactitol. Under conditions of hyperglycemia, sorbitol accumulation occurs. Aldose reductase inhibitors prevent the accumulation of intracellular sorbitol.”
http://www.raysahelian.com/rutin.html
The Natural Health Benefits of Rutin
“One key benefit of rutin is its ability to strengthen the lining of the blood vessels throughout the body to reduce bleeding and prevent them from collapsing. One way it accomplishes this is through oxerutins, which are a group of flavonoid chemicals derived from naturally occurring rutin and which have been used in European supplements since the 1960s for treating and preventing varicose veins and leg ulcers. According to University of Maryland Medical Center, “A number of studies have shown that flavonoids that come from rutin relieve swelling, aching, and pain from varicose veins.” Because rutin strengthens arteries and veins, it is also used to help treat hemorrhoids, internal bleeding, and to help prevent hemorrhagic strokes.
What’s more, studies show that rutin may also be able to stop the formation of blood clots (thrombosis) altogether. This would be quite a health benefit, as thrombosis is one of the leading causes of death in the US. Not only can blood clots cause heart attacks and strokes, but deep venous thrombosis (DVT) and pulmonary embolisms as well. Rutin is proving to be very effective with blood clots because it helps treat and prevent clots in both arteries and veins. Clots in arteries are platelet-rich and clots in veins are fibrin-rich. A study published in the Harvard Gazette suggests that this could be a safe alternative to aspirin, Plavix, and warfarin (Coumadin). The authors add that even while on these drugs, each year there are approximately 400,000 recurrent episodes among patients who previously experienced a stroke or heart attack. “Rutin proved to be the most potently anti-thrombotic compound that we ever tested,” said Robert Flaumenhaft, an investigator in the Division of Hemostasis and Thrombosis at BIDMC and associate professor of medicine at Harvard Medical School.”
https://jonbarron.org/herbal-library/nutraceuticals/rutin
ARTHRITIS
The following article is another great source of rutin research.
Rutin Health Benefits
“The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation. Intraperitoneal administration of rutin, quercetin (flavonols) and hesperidin (flavanone), given at daily doses equivalent to 80 mg/kg, inhibited both acute and chronic phases of this experimental model of inflammation. Rutin was the most active in the chronic phase.”
https://www.zhion.com/phytonutrients/Rutin.html
AUTISM
Autistic kids improved when taking a combination of Flavonoids
Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
https://www.nature.com/articles/tp2015142
BRAIN – CNS - CENTRAL NERVOUS SYSTEM
The flavonoid rutin induces astrocyte and microglia activation and regulates TNF-alpha and NO release in primary glial cell cultures
https://link.springer.com/article/10.1007%2Fs10565-007-9017-y
CANCER
Rutin mediated targeting of signaling machinery in cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260193/
In vitro Protective Effect of Rutin and Quercetin against Radiation-induced Genetic Damage in Human Lymphocytes
“Treatment of lymphocytes with RUT and QRT (25 μg/ml) prior exposure to 2 Gy gamma radiation resulted in a significant reduction of frequency of micronuclei as compared to the control set of cells evaluated by CBMN assay. Similarly, treatment of lymphocytes with RUT and QRT before radiation exposure showed significant decrease in the DNA damage as assessed by comet parameters, such as percent tail DNA and olive tail moment.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672749/
Across the board Rutin makes everything better, especially all those poisonous drug side effects. Here is how Rutin ameliorates the toxicity of chemotherapy.
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1069-1
INFLAMMATORY BOWEL DISEASE
This is an incredibly well researched article, with 135 listed references. Unfortunately, they come to an insipid conclusion. Is it because it would put the funders of their studies out of business? I don’t know about you, but with my lifetime of bowel troubles, I’m taking my rutin.
Flavonoids in Inflammatory Bowel Disease: A Review
“The different studies performed with flavonoids focused on their intestinal anti-inflammatory effect can definitively support their consideration as potential treatments for human IBD. In fact, flavonoids have shown efficacy in experimental models and their mechanisms of action are similar to those described for drugs currently used in human therapy. Besides, their consumption in edible vegetables from ancient times makes them a safe strategy. However, there is a clear demand for clinical trials to confirm their actual role in the treatment of these intestinal inflammatory conditions. Most of the studies carried out in humans consider the use of plants containing flavonoids, and they have shown that these plants may induce clinical remission and clinical response in patients with IBD, although more studies including larger number of patients are required to achieve more solid conclusions. Nevertheless, a pilot study has been carried out to evaluate the efficacy of the oral administration of EGCG and has reported beneficial effects on UC patients refractory to 5-ASA and/or azathioprine. Further clinical studies should definitely be done to elucidate the efficacy and safety of the different flavonoids in these intestinal inflammatory conditions and to finally consider them as solid therapeutic strategies.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848680/
IRON OVERLOAD/TOXICITY
Ameliorating Role of Rutin on Oxidative Stress Induced by Iron Overload in Hepatic Tissue of Rats
“From the obtained results it could be concluded that, the natural flavonoids, rutin inhibited the adverse effect of ferric ion induced oxidative stress by reducing protein and DNA oxidation and inhibition of lipid peroxidation in liver tissue due to its marked hepatoprotective role in the experimental rats.”
https://scialert.net/fulltext/?doi=pjbs.2014.964.977
LIVER
Rutin ameliorates intentional liver poisoning in rats.
Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863108/
Imagine how rutin may benefit a person who has been using any kind of drug long term. If you are taking drugs, speak to your doctor first before adding rutin.
Rutin is NOT a drug.
“Drug-induced liver injury is responsible for 5% of all hospital admissions, and 50% of all acute liver failures.”
https://en.wikipedia.org/wiki/Hepatotoxicity
MACULAR DEGNERATION
There is a very thin layer of melanin in the back of the eye, where the nutrients and oxygen are transferred.
https://pdfs.semanticscholar.org/2119/3283f2416ee783000bc509289c8aae882e89.pdf
NERVE PAIN – NEUROPATHY
The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy
http://journals.sagepub.com/doi/abs/10.1186/1744-8069-9-53
OXIDATIVE DAMAGE
Rutin is clearing out the wastes of ROS, reactive oxygen species.
Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells.
https://www.ncbi.nlm.nih.gov/pubmed/19931526
PARKINSON’S DISEASE
Parkinson's Disease can be ameliorated with Flavonoids, just how far is yet to be determined.
Table 1 in this article gives a great breakdown of Flavonoids, their sources, and structure of the molecule itself.
Protective Mechanisms of Flavonoids in Parkinson's Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630416/
SKIN
Early treatment with rutoside and ascorbic acid is highly effective for progressive pigmented purpuric dermatosis.
https://www.ncbi.nlm.nih.gov/pubmed/25482694
TMJ – TEMPOROMANDIBULAR JOINT
Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535474/
UV LIGHT PROTECTION
Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation
“Rutin reduced UV-induced proinflammatory response and ROS generation and enhanced the activity/levels of antioxidants (SOD, GSH-Px, vitamin E, GSH, and Trx).”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266866/
VITAMIN C EFFICACY
I love early studies on vitamins and minerals. They are easy to understand, and generally are not written for the sole purpose of making money be creating a drug. This is a study from 1949 on how rutin helps the liver of guinea pigs retain vitamin C.
The Effect of Oral Administration of Rutin on Blood, Liver and Adrenal Ascorbic Acid and on Liver and Adrenal Cholesterol in Guinea Pigs: One Figure
https://academic.oup.com/jn/article-abstract/37/4/531/4727740?redirectedFrom=PDF
SOY ISOFLAVONE
.Soy isoflavone is another type of flavonoid. There is some misinformation out there about soy isoflavones and cell signaling and those being endocrine disruptors as they are phytoestrogens. Soy isoflavones have been beneficial for some women going through menopause.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713750/
Here is a 'bad' article from Weston Price about Soy Isoflavones.
https://www.westonaprice.org/health-topics/soy-alert/soy-isoflavones-panacea-or-poison/
If you decide to supplement with Soy Isoflavones, be sure to understand a little bit about phytoestrogens, and signaling cascades.
Biochemical Cascade
https://en.wikipedia.org/wiki/Biochemical_cascade
THE DARK PROTEOME
If you read the article above about Albert Gyorgi, you will notice that he describes the looks of the protein as a ‘swiss chocolate.' This darkness, this coloration keeps popping up on the radar screen. Its in our brains as neuromelanin, and that's why our substantia nigra, notice nigra, is called nigra, black, because that part of our body should be loaded with it.
There are two definitive cases where our brain is not loaded with dark pigment and they are in the first 3 years of our lives, and in the case of Parkinson's, where the substantia nigra and reticulum are depleted of their naturally dark coloration. The substantia nigra is where we have control over our motor functions, our bodily movements.
Babies and people with Parkinson's do not have motor control and/or hand eye coordination. I don't want to go to deep into this here, but we have no business putting neurotoxins into little children for the simple fact that neuromelanin helps us detox heavy metals, and a child has no way to detox heavy metals out of the brain without neuromelanin. Human children don’t produce neuromelanin in their brains until between 2 and 3 years of age.
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187132/
Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection
“In total 1,000 proteins were identified associated with neuromelanin granules.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107900/
This leads us to the 'Dark Proteome.'
https://en.wikipedia.org/wiki/Proteome#Dark_proteome
An in-depth article on the ‘Dark Proteome.’
Unexpected features of the dark proteome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702990/
I will touch on Manganese, and the odd anti-ferromagnetism, and that manganese is dark, and that when it is studied to see how it actually helps plants perform photosynthesis, to break out the oxygen that you and I are breathing, when they try to capture the image of it, the manganese changes its behavior. We still don’t know how photosynthesis works.
Photosystem II
“The mechanism of water oxidation is still not fully elucidated, but we know many details about this process.”
https://en.wikipedia.org/wiki/Photosystem_II
We want brown fats, and this is how rutin works with it.
https://www.fasebj.org/doi/abs/10.1096/fj.201600459RR
MY HISTORY WITH RUTIN
I took Bioflavonoids for years for my almost constant stomach pain for a duodenal ulcer, probably caused by H. Pylori. I stopped using them several years ago as I felt that they were treating a symptom, and they weren't solving the problem.
Now I understand, I need bioflavonoids everyday, like I breathe, eat, and drink water everyday.
Taking loads of supplements, without flavonoids, is like trying to build a building, where we have all the parts, the bricks, the wood for the frame and floors, the buckets of paint, even the piping, the furnace, but we are missing the glue and nails and solder that put it all together.
Flavonoids give us that interstitial space between the goodness. The white parts of the citrus that holds the whole fruit together, those almost collagen looking parts that wall off the sections of an orange, there is a lot of misinformation about them.
This reminds me of how in anatomy they would basically dissect a body with the intention of getting to the organs, and say "Let's get this white webbing stuff out of the way," the messentery, without understanding its true purpose.
SUMMARY
.If you are taking huge amounts of supplements, and your condition, and your symptoms never seem to change, you may be deficient in flavonoids.
Flavonoids are not something that can be measured. There is no hair, or blood test for recording your ‘flavonoid’ levels. This is because the body readily breaks up flavonoids for immediate use.
During our lifetimes, many of us grew broken, like humpty dumpty who fell off the wall. We were supposed to have more energy from our magnesium. The sulfur we started ingesting was supposed to help us recover our skin, and inflamed intestines. The Iodine we have been taking doesn’t really seem to give us newfound energy, and our body temperature remains low, or we get constant hot flashes.
To connect these essentials together, to have our body put them to good use, we may need a substantial increase in flavonoids. Flavonoids are the workers behind the scenes in our factory, our body. They are the mortar between the bricks. We may be taking all the supplements in the world, but without flavonoids, the glue to put us, our model humans back together, we may feel like a box of mismatched parts.
I’m currently taking 1 gram of rutin flavonoid everyday.
Albert Wilkling
April 26, 2018
HOLISTIC AND NATURAL
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